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7 Hydroxymitragynine

7-Hydroxymitragynine (7-OH) is a potent indole alkaloid and the active metabolite of... Read More

7-Hydroxymitragynine (7-OH) is a potent indole alkaloid and the active metabolite of mitragynine, the primary alkaloid found in the kratom plant (Mitragyna speciosa). While mitragynine does not directly activate opioid receptors, its metabolite, 7-OH, exhibits high binding affinity to the μ-opioid receptors, directly activating them and resulting in opioid-like effects, including analgesia, sedation, and euphoria. Due to its high potency and rapid onset, 7-OH is recognized for its significant antinociceptive effect, often reported as being 40 times more powerful than mitragynine and up to 13 times more potent than morphine in certain animal studies.

Definition and Structure of 7-Hydroxymitragynine

7-Hydroxymitragynine (7-OH) is a naturally occurring indole alkaloid found in the leaves of the kratom plant (Mitragyna speciosa). As a metabolite of mitragynine, 7-OH is integral to kratom’s opioid-like effects. Its unique chemical structure allows it to bind effectively to opioid receptors, producing significant analgesic and euphoric effects. The molecular formula of 7-OH is C23H30N2O5, and it has a molecular weight of 414.51 g/mol. This structural specificity is what gives 7-OH its high potency and rapid onset of action, distinguishing it from other kratom alkaloids.

Kratom Extracts

Commercial kratom products and extracts vary widely in alkaloid content, with kratom's primary alkaloid, mitragynine, being a significant component. 7-Hydroxymitragynine is usually present in low concentrations in raw leaf but becomes more prominent in concentrated kratom extracts. It is considered one of kratom’s most pharmacologically active compounds, contributing substantially to its analgesic effects. The combination of mitragynine and 7-hydroxymitragynine plays a critical role in shaping the overall pharmacological activity of kratom preparations.

Active Metabolite

Indole alkaloids, such as 7-OH, act as the main active metabolite of mitragynine, formed primarily in the liver through enzymatic conversion. Studies in human liver microsomes and rodent models support its contribution to kratom’s pharmacological effects, particularly in managing pain and producing sedative effects. Its action as a partial agonist at opioid receptors, with competitive antagonist properties at certain other receptor sites, further illustrates its complex mechanism of action.

Kratom Plant

Mitragyna speciosa, a tropical tree native to Southeast Asia, has been used for centuries as a traditional herbal remedy. The plant's leaves are rich in over 40 active compounds, with mitragynine and 7-hydroxymitragynine being the most well-studied. These kratom alkaloids are responsible for the plant's stimulant effects at lower doses and sedative, pain-relieving effects at higher doses.

7 OH

In kratom formulations, "7 OH" refers to 7-hydroxymitragynine. Found in both full-spectrum and enhanced kratom extracts, 7-OH is often favored by experienced kratom users for its fast-acting and powerful effects. Scientific data and prior literature support its role as a key alkaloid in therapeutic potential, particularly for those seeking natural alternatives for pain relief or managing opioid withdrawal symptoms.

Drug Interactions

Due to its action on the opioid receptors, 7-hydroxymitragynine may interact with other opioids, sedatives, and drugs that affect liver enzymes. These drug interactions can increase the risk of respiratory depression or lead to unpredictable effects. Users should be cautious and consult healthcare providers before combining kratom extracts with other substances.

Kratom Use

The rise of kratom use in Western countries has paralleled growing concerns over the opioid epidemic. Some users turn to kratom products, particularly those containing higher concentrations of 7-OH, as alternatives to prescription opioids. However, the drug enforcement administration (DEA) and FDA have raised concerns over its abuse liability, physical dependence, and potential for adverse effects.

Kratom Products

7-Hydroxymitragynine is featured in many commercial kratom products, including chewable tablets, liquid shots, and kratom extract capsules. These premium kratom products often highlight their alkaloid content, offering standardized dosing for consistent and reliable experience. Products labeled as high strength kratom extract are typically intended for veteran users seeking enhanced focus, stress relief, or pain management.

Kratom Leaves

The raw leaf of the kratom plant contains a mix of alkaloids, with mitragynine being the most abundant. However, due to the low natural occurrence of 7-OH in raw leaf, modern kratom preparations isolate or enhance this alkaloid to improve efficacy. Extracts that boost 7-OH content can offer greater potency and rewarding effects.

Commercial Kratom Products

Kratom products in the market, such as those with 7tabz or Opia chewable tablets, often emphasize potency, quality, and purity. These products undergo rigorous testing and adhere to Good Manufacturing Practices (GMP), ensuring that users get the most from their kratom experience while minimizing the risk of contamination or inconsistent alkaloid levels.

Binding Affinity

7-Hydroxymitragynine demonstrates superior binding affinity to the opioid receptor compared to mitragynine. This increased receptor activity accounts for its greater potency and is central to its analgesic and sedative properties. Researchers continue to explore its abuse potential, tolerance development, and reinforcing effects in animal studies.

Mitragyna Speciosa

As a promising medicinal plant, Mitragyna speciosa remains under active investigation for its therapeutic potential. While some data supports its use for pain relief, anxiety, and opioid withdrawal, the need for further scientific research remains. Findings suggest that careful dosing, understanding drug interactions, and using lab-tested products can reduce risks associated with kratom use.

Mitragynine and 7

Together, mitragynine and 7-hydroxymitragynine form a potent synergy in kratom extracts. While mitragynine provides a base of energizing effects, 7-OH enhances analgesia and sedation. Their combined action at the μ-opioid receptors reflects a unique profile distinct from traditional opioids, offering users a potentially safer but still powerful alternative for managing pain and supporting well-being.

Explore premium kratom products containing 7-hydroxymitragynine, including Opia chewable tablets and 7Tabz, at DeltaCloudz — your trusted source for lab-tested, high-quality kratom extracts.